因果推理提供了一种语言，以提出纯粹统计关联以外的重要介入和反事实问题。例如，在医学成像中，我们可能希望研究遗传，环境或生活方式因素对解剖表型正常和病理变异的因果关系。但是，尽管可以可靠地构建从自动图像分割中提取的3D表面网格的解剖形状模型，但缺乏计算工具来实现有关形态变化的因果推理。为了解决这个问题，我们提出了深层结构性因果形状模型（CSM），该模型利用了高质量的网格生成技术，从几何深度学习，在深层结构性因果模型的表达框架内。 CSM可以通过反事实网格产生来实现特定于受试者的预后（“如果患者大十岁，该患者的大脑结构将如何变化？”），这与大多数当前有关纯粹人口级统计形状建模的作品形成鲜明对比。我们通过许多定性和定量实验利用了3D脑结构的大数据集，证明了Pearl因果关系层次结构的所有级别CSM的能力。

生物医学中的多模式数据遍布，例如放射学图像和报告。大规模解释这些数据对于改善临床护理和加速临床研究至关重要。与一般领域相比，具有复杂语义的生物医学文本在视觉建模中提出了其他挑战，并且先前的工作使用了缺乏特定领域语言理解的适应性模型不足。在本文中，我们表明，有原则的文本语义建模可以大大改善自我监督的视力 - 语言处理中的对比度学习。我们发布了一种实现最先进的语言模型，从而通过改进的词汇和新颖的语言预测客观的客观利用语义和话语特征在放射学报告中获得了自然语言推断。此外，我们提出了一种自我监督的联合视觉 - 语言方法，重点是更好的文本建模。它在广泛的公开基准上建立了新的最新结果，部分是通过利用我们新的特定领域的语言模型。我们释放了一个新的数据集，该数据集具有放射科医生的局部对齐短语接地注释，以促进生物医学视觉处理中复杂语义建模的研究。广泛的评估，包括在此新数据集中，表明我们的对比学习方法在文本语义建模的帮助下，尽管仅使用了全球对准目标，但在细分任务中的表现都优于细分任务中的先验方法。

Traditionally, data analysis and theory have been viewed as separate disciplines, each feeding into fundamentally different types of models. Modern deep learning technology is beginning to unify these two disciplines and will produce a new class of predictively powerful space weather models that combine the physical insights gained by data and theory. We call on NASA to invest in the research and infrastructure necessary for the heliophysics' community to take advantage of these advances.

Plastic shopping bags that get carried away from the side of roads and tangled on cotton plants can end up at cotton gins if not removed before the harvest. Such bags may not only cause problem in the ginning process but might also get embodied in cotton fibers reducing its quality and marketable value. Therefore, it is required to detect, locate, and remove the bags before cotton is harvested. Manually detecting and locating these bags in cotton fields is labor intensive, time-consuming and a costly process. To solve these challenges, we present application of four variants of YOLOv5 (YOLOv5s, YOLOv5m, YOLOv5l and YOLOv5x) for detecting plastic shopping bags using Unmanned Aircraft Systems (UAS)-acquired RGB (Red, Green, and Blue) images. We also show fixed effect model tests of color of plastic bags as well as YOLOv5-variant on average precision (AP), mean average precision (mAP@50) and accuracy. In addition, we also demonstrate the effect of height of plastic bags on the detection accuracy. It was found that color of bags had significant effect (p < 0.001) on accuracy across all the four variants while it did not show any significant effect on the AP with YOLOv5m (p = 0.10) and YOLOv5x (p = 0.35) at 95% confidence level. Similarly, YOLOv5-variant did not show any significant effect on the AP (p = 0.11) and accuracy (p = 0.73) of white bags, but it had significant effects on the AP (p = 0.03) and accuracy (p = 0.02) of brown bags including on the mAP@50 (p = 0.01) and inference speed (p < 0.0001). Additionally, height of plastic bags had significant effect (p < 0.0001) on overall detection accuracy. The findings reported in this paper can be useful in speeding up removal of plastic bags from cotton fields before harvest and thereby reducing the amount of contaminants that end up at cotton gins.

There is considerable interest in predicting the pathogenicity of protein variants in human genes. Due to the sparsity of high quality labels, recent approaches turn to \textit{unsupervised} learning, using Multiple Sequence Alignments (MSAs) to train generative models of natural sequence variation within each gene. These generative models then predict variant likelihood as a proxy to evolutionary fitness. In this work we instead combine this evolutionary principle with pretrained protein language models (LMs), which have already shown promising results in predicting protein structure and function. Instead of training separate models per-gene, we find that a single protein LM trained on broad sequence datasets can score pathogenicity for any gene variant zero-shot, without MSAs or finetuning. We call this unsupervised approach \textbf{VELM} (Variant Effect via Language Models), and show that it achieves scoring performance comparable to the state of the art when evaluated on clinically labeled variants of disease-related genes.

In this paper, we propose a new approach to learned optimization. As common in the literature, we represent the computation of the update step of the optimizer with a neural network. The parameters of the optimizer are then learned on a set of training optimization tasks, in order to perform minimisation efficiently. Our main innovation is to propose a new neural network architecture for the learned optimizer inspired by the classic BFGS algorithm. As in BFGS, we estimate a preconditioning matrix as a sum of rank-one updates but use a transformer-based neural network to predict these updates jointly with the step length and direction. In contrast to several recent learned optimization approaches, our formulation allows for conditioning across different dimensions of the parameter space of the target problem while remaining applicable to optimization tasks of variable dimensionality without retraining. We demonstrate the advantages of our approach on a benchmark composed of objective functions traditionally used for evaluation of optimization algorithms, as well as on the real world-task of physics-based reconstruction of articulated 3D human motion.

We study the fundamental task of outlier-robust mean estimation for heavy-tailed distributions in the presence of sparsity. Specifically, given a small number of corrupted samples from a high-dimensional heavy-tailed distribution whose mean $\mu$ is guaranteed to be sparse, the goal is to efficiently compute a hypothesis that accurately approximates $\mu$ with high probability. Prior work had obtained efficient algorithms for robust sparse mean estimation of light-tailed distributions. In this work, we give the first sample-efficient and polynomial-time robust sparse mean estimator for heavy-tailed distributions under mild moment assumptions. Our algorithm achieves the optimal asymptotic error using a number of samples scaling logarithmically with the ambient dimension. Importantly, the sample complexity of our method is optimal as a function of the failure probability $\tau$, having an additive $\log(1/\tau)$ dependence. Our algorithm leverages the stability-based approach from the algorithmic robust statistics literature, with crucial (and necessary) adaptations required in our setting. Our analysis may be of independent interest, involving the delicate design of a (non-spectral) decomposition for positive semi-definite matrices satisfying certain sparsity properties.

Recent studies suggest that early stages of diabetic retinopathy (DR) can be diagnosed by monitoring vascular changes in the deep vascular complex. In this work, we investigate a novel method for automated DR grading based on optical coherence tomography angiography (OCTA) images. Our work combines OCTA scans with their vessel segmentations, which then serve as inputs to task specific networks for lesion segmentation, image quality assessment and DR grading. For this, we generate synthetic OCTA images to train a segmentation network that can be directly applied on real OCTA data. We test our approach on MICCAI 2022's DR analysis challenge (DRAC). In our experiments, the proposed method performs equally well as the baseline model.

This paper presents a subsampling-task paradigm for data-driven task-specific experiment design (ED) and a novel method in populationwide supervised feature selection (FS). Optimal ED, the choice of sampling points under constraints of limited acquisition-time, arises in a wide variety of scientific and engineering contexts. However the continuous optimization used in classical approaches depend on a-priori parameter choices and challenging non-convex optimization landscapes. This paper proposes to replace this strategy with a subsampling-task paradigm, analogous to populationwide supervised FS. In particular, we introduce JOFSTO, which performs JOint Feature Selection and Task Optimization. JOFSTO jointly optimizes two coupled networks: one for feature scoring, which provides the ED, the other for execution of a downstream task or process. Unlike most FS problems, e.g. selecting protein expressions for classification, ED problems typically select from highly correlated globally informative candidates rather than seeking a small number of highly informative features among many uninformative features. JOFSTO's construction efficiently identifies potentially correlated, but effective subsets and returns a trained task network. We demonstrate the approach using parameter estimation and mapping problems in clinically-relevant applications in quantitative MRI and in hyperspectral imaging. Results from simulations and empirical data show the subsampling-task paradigm strongly outperforms classical ED, and within our paradigm, JOFSTO outperforms state-of-the-art supervised FS techniques. JOFSTO extends immediately to wider image-based ED problems and other scenarios where the design must be specified globally across large numbers of acquisitions. Code will be released.

诸如DALL-E 2之类的生成模型可以代表放射学中人工智能研究的图像生成，增强和操纵的有希望的未来工具，前提是这些模型具有足够的医疗领域知识。在这里，我们证明DALL-E 2在零拍的文本到图像生成方面，学习了具有有希望的功能的X射线图像的相关表示，将图像的延续超出其原始边界或删除元素，尽管病理产生或CT，MRI和超声图像仍然受到限制。因此，即使事先需要对这些模型进行进一步的微调和适应，也需要使用生成模型来增强和生成放射学数据似乎是可行的。